26520-1-AP targets Vinculin in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat, Canine samples.

Tested ApplicationsWB, IF/ICC, IHC, ELISA Application Description

Cited ApplicationsWB, IF

Tested ReactivityHuman, Mouse, Rat, Canine

Cited ReactivityHuman, Mouse, Rat, Rabbit, Pig

ImmunogenVinculin fusion protein Ag24942 种属同源性预测

Host / IsotypeRabbit / IgG

ClassPolyclonal

TypeAntibody

Full Namevinculin

SynonymsCMD1W, Metavinculin, MVCL, VCL, Vinculin

Calculated Molecular Weight1133 aa, 124 kDa

Observed Molecular Weight117 kDa

GenBank Accession NumberBC039174

Gene SymbolVCL

Gene ID (NCBI)7414

RRIDAB_2868558

ConjugateUnconjugated

FormLiquid

Purification MethodAntigen affinity purification

UNIPROT IDP18206

Storage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Vinculin belongs to the vinculin/alpha-catenin family. It is an actin filament (F-actin)-binding protein which involved in cell-matrix adhesion and cell-cell adhesion. Vinculin regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. It may also play important roles in cell morphology and locomotion. Vinculin is a 117-kDa, 1,066-amino-acid protein which is ubiquitously expressed. Its splice variant, metavinculin (124 kDa), is muscle-specific.