26520-1-AP targets Vinculin in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat, Canine samples.
Tested ApplicationsWB, IF/ICC, IHC, ELISA Application Description
Cited ApplicationsWB, IF
Tested ReactivityHuman, Mouse, Rat, Canine
Cited ReactivityHuman, Mouse, Rat, Rabbit, Pig
ImmunogenVinculin fusion protein Ag24942 种属同源性预测
Host / IsotypeRabbit / IgG
ClassPolyclonal
TypeAntibody
Full Namevinculin
SynonymsCMD1W, Metavinculin, MVCL, VCL, Vinculin
Calculated Molecular Weight1133 aa, 124 kDa
Observed Molecular Weight117 kDa
GenBank Accession NumberBC039174
Gene SymbolVCL
Gene ID (NCBI)7414
RRIDAB_2868558
ConjugateUnconjugated
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDP18206
Storage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
背景介绍
Vinculin belongs to the vinculin/alpha-catenin family. It is an actin filament (F-actin)-binding protein which involved in cell-matrix adhesion and cell-cell adhesion. Vinculin regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. It may also play important roles in cell morphology and locomotion. Vinculin is a 117-kDa, 1,066-amino-acid protein which is ubiquitously expressed. Its splice variant, metavinculin (124 kDa), is muscle-specific.